The MotoGP Layout at Indianapolis Motor Speedway represents the motorcycle road racing configuration utilizing the legendary oval's infield road course sections combined with portions of the 2.5-mile superspeedway. The MotoGP designation indicates the specific routing used when the circuit hosted MotoGP motorcycle racing from 2008-2015. This variant demonstrates Indianapolis Motor Speedway's versatility beyond its famous Indianapolis 500 oval mission, serving motorcycle racing's premier championship at the Brickyard.

Operating the MotoGP Layout showcases Indianapolis Motor Speedway's comprehensive infrastructure where multiple road course configurations serve diverse motorsport disciplines beyond the facility's primary oval racing heritage dating to 1909. The layout combined technical infield sections with the oval's banking creating unique motorcycle racing challenges. Indiana's climate creates seasonal racing windows. The MotoGP configuration represents Indianapolis' motorcycle racing era, serving the circuit's role as America's most versatile motorsport venue with oval, road racing, and motorcycle racing capabilities.